INiclosamide Bolus 1250 mg
I-Niclosamide Bolus ithintela i-phosphorylation kwi-mitochondria ye-cestodes. Kokubini kwi-vitro nakwi-vivo, ii-scolex kunye nee-proximal segments ziyabulawa xa zidibene neyeza. I-scolex ekhululekileyo inokwetyiswa emathunjini; ngenxa yoko, kusenokungabi lula ukubona i-scolex ekwindle. I-Niclosamide Bolus iyasebenza kwi-taenicidal kwaye ayisusi kuphela ii-segments kodwa ikwasusa ne-scolex.
Umsebenzi weNiclosamide Bolus ngokuchasene neempethu ubonakala ngathi ubangelwa kukuthintelwa kwe-phosphorylation ye-oxidative ye-mitochondrial; imveliso ye-ATP engashukumiyo nayo iyachaphazeleka.
Umsebenzi we-cestocidal weNiclosamide Bolus ubangelwa kukuthintela ukufunxwa kweglucose yi-tapeworm kunye nokuhlanganiswa kwenkqubo ye-oxidative phosphorylation kwi-mitochondria ye-cestodes. I-lactic acid eqokelelweyo evela ekuthintelweni komjikelo weKrebs ibulala iimpethu.
Iimpawu
I-Niclosamide Bolus ibonakaliswa kwizifo ze-tapeworm kwiMfuyo, kwiiNkukhu, eziNja nakwiiKati nakwi-paramphistomiasis engavuthwanga (i-Amphistomiasis) yeeNkomo, iiMvu neeBhokhwe.
Iimpethu zeTape
Iinkomo, iigusha, iibhokhwe kunye neenyamakazi: Iintlobo zeMoniezia iThysanosoma (iimpethu ezifakwe iintambo)
Izinja: Dipylidium Caninum, Taenia Pisiformis T. hydatigena kunye neT. taeniaeformis.
Amahashe: Usulelo lwe-Anoplocephalid
Iinkuku: Raillietina kunye neDavainea
I-Amphistomiasis: (Iiparamphistomes ezingekavuthwa)
Kwiinkomo nakwiigusha, ii-Rumen flukes (iintlobo zeParamphistomum) zixhaphake kakhulu. Nangona ii-flukes ezindala ezinamathele eludongeni lwe-rumen zinokuba zingenamsebenzi kangako, ezo zingavuthwanga zibangela umonakalo omkhulu kunye nokufa ngelixa zifudukela eludongeni lwe-duodenal.
Izilwanyana ezibonisa iimpawu ze-anorexia enzima, ukusela amanzi amaninzi, kunye norhudo oluphuma emanzini kufuneka kurhanelwe ukuba lune-amphistomiasis kwaye lunyangwe ngoko nangoko nge-Niclosamide Bolus ukuthintela ukufa kunye nokulahleka kwemveliso kuba i-Niclosamide Bolus inika ukusebenza okuphezulu rhoqo ngokuchasene neentsholongwane ezingavuthwanga.
Ukwakhiwa
I-bolus nganye engagqunywanga iqulethe:
I-Niclosamide IP 1.0 gm
Ulawulo kunye nomthamo
I-Niclosamide Bolus ekutyeni okanye njalo njalo.
Ukulwa neentshulube zeTape
Iinkomo, iigusha namahashe: 1 gm bolus kwi-20 kg ubunzima bomzimba
Izinja kunye neekati: 1 gm bolus yobunzima bomzimba obuyi-10 kg
Iinkuku: 1 gm bolus kwiintaka ezi-5 ezindala
(Phantse i-175 mg ngekhilogram yobunzima bomzimba)
Ngokuchasene ne-Amphistomes
Iinkomo neegusha:Idosi ephezulu ngesantya se-1.0 gm bolus / ubunzima bomzimba obuyi-10 kg.
Ukhuseleko:I-Niclosamide bolus inomlinganiselo omkhulu wokhuseleko. Ukugqithisa i-Niclosamide ukuya kuthi ga kwizihlandlo ezingama-40 kwiigusha nakwiinkomo kufunyenwe kungenabungozi. Kwizinja nakwiikati, idosi ephindwe kabini ecetyiswayo ayibangeli miphumo mibi ngaphandle kokuthamba kwendle. I-Niclosamide bolus ingasetyenziswa ngokukhuselekileyo kuzo zonke izigaba zokukhulelwa nakubantu ababuthathaka ngaphandle kwemiphumo emibi.
