I-Niclosamide Bolus 1250 mg
I-Niclosamide Bolus inqanda i-phosphorylation kwi-mitochondria ye-cestodes.Zombini i-in vitro kunye ne-vivo, i-scolex kunye ne-proximal segment zibulawa ngokudibana nechiza.I-scolex ekhululekileyo inokwetyiswa emathunjini;ngenxa yoko, kusenokungenzeki ukuchonga i-scolex kwilindle.I-Niclosamide Bolus yi-taenicid kwisenzo kwaye ayipheli kuphela amacandelo kodwa kunye ne-scolex.
Umsebenzi weNiclosamide Bolus ngokuchasene neentshulube ubonakala ubangelwa kukuthintelwa kwe-mitochondrial oxidative phosphorylation;Imveliso ye-ATP ye-anaerobic nayo ichaphazelekayo.
Umsebenzi we-cestocidal we-Niclosamide Bolus kungenxa yokuthintela ukufunxwa kwe-glucose yi-tapeworm kunye nokudityaniswa kwenkqubo ye-oxidative phosphorylation kwi-mitochondria ye-cestodes.I-asidi ye-lactic eqokelelweyo ephuma ekuvalelekeni komjikelo we-Krebs ibulala iintshulube.
Iimpawu
INiclosamide Bolus ibonakaliswe kuzo zombini iintshulube zetapeworm ezihlasela imfuyo, iinkukhu, izinja kunye neekati kunye nakwi paramphistomiasis (Amphistomiasis) engekavuthwa yeenkomo, iigusha kunye neebhokhwe.
Iintshulube ze tapeworm
Iinkomo, iibhokhwe zeegusha kunye namaxhama: iMoniezia Species Thysanosoma (iiNtshulube zeTape eziFringed)
Izinja: I-Dipylidium Caninum, i-Taenia Pisiformis T. hydatigena kunye ne-T. taeniaeformis.
Amahashe: Usulelo lweAnoplocephalid
Iinkukhu: URaillietina kunye noDavainea
Amphistomiasis: (IParamphistomes engekavuthwa)
Kwiinkomo kunye neegusha, iRumen flukes (iintlobo zeParamphistomum) zixhaphake kakhulu.Ngelixa iiFlukhwe zabantu abadala ezincanyathiselwe kudonga lwerumen zinokungabalulekanga kangako, ezingekavuthwa zibangela umonakalo omkhulu kunye nokufa ngelixa zifudukela kudonga lweduodenal.
Izilwanyana ezibonisa iimpawu zeanorexia, ukwanda kwamanzi, kunye norhudo olunamanzi kufuneka lurhanelwe nge-amphistomiasis kwaye lunyangwe kwangoko ngeNiclosamide Bolus ukunqanda ukufa kunye nokulahleka kwemveliso kuba i-Niclosamide Bolus ibonelela ngokusebenza okuphezulu okuthe gqolo ngokuchasene neentlupheko ezingekafiki.
Ukuqamba
Ibholi nganye engagqunywanga iqulethe:
I-Niclosamide IP 1.0 gm
Ulawulo kunye nethamo
I-Niclosamide Bolus kwisondlo okanye ngolo hlobo.
Ngokuchasene neTapeworms
Iinkomo, iigusha kunye namaHashe: 1 gm bolus kubunzima bomzimba obungama-20 kg
Izinja neekati: 1 gm bolus nge-10 kg ubunzima bomzimba
Iinkukhu: 1 gm bolus kwiintaka ezi-5 zabantu abadala
(Ngokumalunga ne-175 mg ngekhilogram yobunzima bomzimba)
Ngokuchasene neAmphistomes
Iinkomo neegusha:Idosi ephezulu kwireyithi ye-1.0 gm bolus / 10 kg ubunzima bomzimba.
Ukhuseleko:I-Niclosamide bolus inomda obanzi wokhuseleko.Ukusetyenziswa ngokugqithisileyo kwe-Niclosamide ukuya kumaxesha angama-40 kwiigusha nakwiinkomo kufunyaniswe ukuba ayinayo ityhefu.Kwizinja neekati, umthamo ophindwe kabini ocetyiswayo awubangeli iziphumo zibi ngaphandle kokuthamba kwelindle.I-Niclosamide bolus inokusetyenziswa ngokukhuselekileyo kuzo zonke izigaba zokukhulelwa kunye nakwizifundo ezibuthathaka ngaphandle kwemiphumo emibi.
