I-Colistin Sulfate Pharmacology kunye neSikhokelo sokwenziwa kwezonyango esisebenzayo soogqirha bezilwanyana

I-Colistin sulfate sisixhobo esisetyenziswa kakhulu ekulweni neentsholongwane ezibanzi kwiifama zezilwanyana. Nangona kunjalo, uninzi lwabalimi kunye noogqirha bezilwanyana bayazi igama layo kuphela ngaphandle kokuqonda ukusetyenziswa okumiselweyo nokujoliswe kuko. Kuphela ngokuqonda ngokupheleleyo iipropati zayo zokulwa neentsholongwane, ukwamkela imixube ejoliswe kuko kunye nolawulo olumiselweyo apho sinokusebenzisa khona amayeza ukuze sifumane impendulo ekhawulezileyo kunye namazinga aphezulu okunyanga.

Amayeza ezilwanyana asebenzayo awaxhomekekanga kumaxabiso aphantsi, kodwa kubuchule obupheleleyo beempawu zamayeza. Okukhona uqonda ngakumbi iyeza, kokukhona ukhetha ngokuchanekileyo amayeza akho, nto leyo eya kubeka isiseko esiqinileyo sokuchongwa nonyango olusebenzayo lwesifo. I-Colistin sulfate powder enyibilikayo liyeza eliqhelekileyo lamathumbu kunyango lweenkukhu kunye nemfuyo, kodwa bambalwa abasebenzi abaphambili abaqonda ngokupheleleyo iimpawu zalo kunye nemithetho emiselweyo yokuhambelana.

1. Ukuchongwa kwezinto eziluhlaza kunye nokwahlulwa koMgangatho weMveliso

I-Colistin sulfate yi-antibiotiki yendalo ye-alkaline polypeptide ekhutshwa ngokubiliswa kwezinto eziphilayo. Imveliso yayo ecocekileyo eqhelekileyo yipowder emhlophe, inyibilika kakhulu emanzini acocekileyo, kwaye ayinyibiliki phantse kuzo zonke izinyibilikisi zendalo. Ezinye iimveliso zomgubo onyibilikayo we-colistin sulfate zorhwebo zibonakala zimthubi, zibomvu okanye zipinki xa sele zisusiwe. Ezi mveliso azihlangabezani nemigangatho yobumsulwa bezinto eziluhlaza kwaye zibalwa njengezinto ezingaphantsi, ezingacetyiswayo ukuba zisetyenziswe eklinikhi. Ngenxa yokunyibilika kwayo okuncinci kwi-organic solvents, ungayixubi ne-fluid formulations equlethe ubuninzi be-organic solvents xa ulungiselela unyango lokudibanisa amanzi okusela. Nokuba akukho stratification okanye imvula ebonakalayo emva kokuxuba, umsebenzi we-bactericidal we-colistin sulfate uya kuncipha kakhulu emva kokungena kwindlela yokugaya yemfuyo kunye neenkukhu. Kwabogqirha bezilwanyana abaphambili abajonge ukuqinisekisa iziphumo zonyango, ukubeka phambili iimveliso zamayeza ezifanelekileyo linyathelo lokuqala elibalulekileyo. Ukudibanisa amayeza ahambelanayo ngokusekelwe kwiimpawu zawo ze-physicochemical kunye neenkqubo zokuxuba kunye nokulawula ezisemgangathweni kwenza isiqinisekiso esisisiseko semiphumo yokunyanga ezinzileyo.

2. Indlela yokubulala iintsholongwane kunye neSpectrum ye-Antibacterial

Indlela enamandla yokubulala iintsholongwane ye-colistin sulfate: Emva kokusebenza kwiibhaktheriya, eli yeza liyonakalisa ngokungenakuphikiswa isakhiwo se-membrane yeseli yebhaktheriya engeyiyo iGram kwaye landisa kakhulu ukuvuleka kwe-membrane. Izinto ezibalulekileyo zangaphakathi kweseli eziquka i-potassium ions, i-calcium ions, i-amino acids, i-purines kunye ne-pyrimidines ziphuma rhoqo, zicima izinto zenyukliya kunye ne-ribosomes kwaye zibangele i-lysis ekhawulezayo yebhaktheriya kunye nokufa. Eli yeza linoluhlu oluncinci lwe-antibacterial kwaye lisebenza kuphela ngamandla ngokuchasene neentsholongwane ezingeyiyo iGram eziqhelekileyo ekuzaleni, kubandakanya i-Escherichia coli, i-Salmonella, i-Proteus, i-Shigella, i-Pasteurella kunye ne-Pseudomonas aeruginosa. Indlela yalo eyahlukileyo yokubulala iintsholongwane yenza kube nzima kwiibhaktheriya ezibangela izifo ukuba zivelise ukumelana namayeza nxamnye ne-colistin sulfate. Ngaphezu koko, alinawo amandla okulwa nee-antibiotics ezininzi ezinemiqathango embalwa yokuhambelana, okuvumela iinkqubo zokudibanisa eziguquguqukayo.

3. Iimpawu zokufunxa kwi-Vivo kwiSikhokelo seMithi eDibeneyo

Xa inikwa imfuyo esempilweni kunye neenkukhu, i-colistin sulfate ayingeni kakuhle kwi-mucosa yamathumbu ukuze ingene kwi-blood circulation. Kwimeko ye-enteritis okanye i-enterotoxemia ene-intestinal lining eyonakeleyo, engakwazi ukungena kakuhle, malunga ne-10% yeyeza elithathwayo linokungena egazini. Olu phawu lubonelela ngesiseko sethiyori sonyango oludibeneyo olujolise kwizifo zamathumbu eziyinkimbinkimbi zizifo ze-systemic secondary. Eli yeza ligcina uxinaniso oluphezulu lwendawo kwizilonda zamathumbu ukuze kuthintelwe iintsholongwane, ngelixa i-small absorption fraction ilawula usulelo lwe-systemic secondary, inika iziphumo zonyango ezimbini.

4. Iifomula zokuhambelana kweklinikhi eziQhelekileyo

CUnyango oluhlanganisiweyo lwe-colistin sulfate kunye ne-sulfonamides kunye ne-trimethoprim potentiators luneziphumo ezibonakalayo zokubulala iintsholongwane ngokuchasene nezifo ezibangelwa yi-Escherichia coli, i-Pasteurella, i-Salmonella, i-Klebsiella pneumoniae kunye ne-Pseudomonas aeruginosa. Isiphumo sonyango esipheleleyo singcono kakhulu kunolawulo lwe-single colistin sulfate.

Njengeyeza lobuchwephesha lezilwanyanaI-OEMumenzi obonelela ngeemveliso zochungechunge lwe-colistin sulfate kwihlabathi liphelaB2Babasasazi bemfuyo,HEBEI LIHUA PHARMACEUTICAL CO., LTDInika inkxaso epheleleyo kuquka ukuhlolwa kwezinto eziluhlaza, ukwenziwa okwenziwe ngokwezifiso kunye nobonelelo oluzinzileyo lwemfuyo yeenkukhu, iihagu, iigusha kunye namathole. Qhagamshelana nathi ukuze ufumane amaphepha edatha obuchwephesha kunye nezisombululo zentsebenziswano ze-OEM.